Sunday, November 2, 2014

Treatments for OA


            Osteoarthritis (OA) is the most common type of arthritis, and can also be referred to as degenerative joint disease.  Healthy cartilage in the joint permits the bones to move around one another, while also absorbing shocks from physical activity.  The breakdown of the joint tissues (the bones under the cartilage begin to come into contact and rub against one another) is what eventually leads to pain, stiffness, and swelling.  Over time you can get a loss of joint motion, bone spurs (small deposits of bone that grow on the edges of the joint), and pieces of bone/cartilage can detach and float inside the joint space; all of which can lead to increased pain and damage of the diseased area.  The most commonly affected areas are the knees, hips, and those associated with the hands and spine.  Onset of OA is usually after the age of 40 and there is currently no cure.  However, there are ways to relieve symptoms.
            The goals for OA relief include: controlling pain, improving joints function, maintaining normal body weight, and a healthy lifestyle.  The two most common forms of treatment include exercise and weight control.  Exercising will strengthen the muscles that support the affect area(s) while allowing your joints to stay limber.  Maintaining a normal body weight with a healthy lifestyle is also beneficial.  A healthy weight can ensure reduced stress on weight-bearing joints, decrease likelihood of further injuries, and increase mobility.  All of the above are inexpensive and easy enough for the average person to do to improve upon their condition.  However, what if this is not enough?  Are there other plausible options?  The answer is yes.
            There are additional nondrug therapies for OA.   The most interesting is acupuncture.  Scientists believe that the needles stimulate the release of natural, pain-relieving chemicals produced by our bodies.  A study with backing by the NIAMS and NCCAM found that acupuncture relieves pain and increase function in knee OA.  Another interesting therapy includes transcutaneous electrical nerve stimulation (TENS).  TENS is a technique which directs mild electrical pulses to nerve endings under the skin in painful areas.  It is believed that TENS functions by blocking pain messages to the brain and modifies pain perception.
            However, what if these nondrug therapies still aren’t enough?  OA is known for severe pain that can make everyday activities debilitating.  Besides the obvious over-the-counter pain relievers and NSAIDs (nonsteroidal anti-inflammatory drugs i.e. Aspirin, ibuprofen, etc.) is the use of corticosteroids (Cortisone shots).  Corticosteroids are powerful anti-inflammatory hormones naturally made by our body (or man-made for use in medicine).   These hormones are usually produced in your adrenal gland, and when you experience stress, they are released to minimize inflammation. These can be injected into joints to temporarily relieve pain.  However, this is only short term, and not recommended to be used more than two to four times a year due to the known side effects.  Since it is known to cause great relief, even if only for a short amount of time, it would be interesting to see if a new corticosteroid could be synthetically produced that could give longer lasting affects or was able to be used more frequently.
            As our population is living longer and experiencing OA to a long degree, joint replacements are becoming more prevalent.  However, the most extreme treatment for OA is joint-replacement with artificial joints called arthroplasty.  When OA becomes so debilitating and painful that causes normal functioning impossible, many patients become candidates for the procedure.  The most established replacement is with the hip followed by the knee.  In addition, surgeons are exploring new techniques for “minimally invasive” approaches for arthroplasty surgeries.  They are looking into these new methods to give patients a shorts recovery time and less post-op pain.  Also, total hip replacement is a severe surgery.  Hip resurfacing is a surgical alternative.  It consists of scraping the surfaces of the hip joint and femur and placing a metal cap over the bone.  Therefore more of the bone is able to be preserved (allowing for a hip replacement to be done later is needed).  This is a good option for younger patients who are physically active.  There are a variety of surgeries that can be done, the conditions for each depend on the needs of the patient.
            It can be seen that there are multiple ways of relieving pain for OA patients.   These treatments range from mild (exercising and healthy eating) to more intense (Cortisone shots).  Nonetheless, all types of treatment allow for there to be a reduction in pain due to less stress or even a decrease in inflammation which all allow the patient to live a more normal life.  This wide range of treatments allow the individual to choose the best option for them, and hopefully in the near future more will become known and available.



Sources:
McCoy, Krisha. "Pros and Cons of Cortisone for Osteoarthritis."
             EverydayHealth.com. Everyday Health, 10 July 2010. Web. 2 Nov. 2014. <http://www.everydayhealth.com/osteoarthritis/the-pros-and-cons-of-cortisone-for-osteoarthritis.aspx>.

"Osteoarthritis." Handout on Health: Osteoarthritis. National Institute of Arthritis and 
             Musculoskeletal and Skin Diseases (NIAMS), 1 Aug. 2013. Web. 2 Nov. 2014.   
            <http://www.niams.nih.gov/Health_Info/Osteoarthritis/>.

"Osteoarthritis." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 16 May 2014. Web. 2 Nov. 2014. <http://www.cdc.gov/arthritis/basics/osteoarthritis.htm>.

"Osteoarthritis." University of Maryland Medical Center. 25 Sept. 2012. Web. 2 Nov. 2014.<http://umm.edu/health/medical/reports/articles/osteoarthritis>.

9 comments:

  1. Hi Bonnie. It’s good to know there are a variety of treatment options available for people with osteoarthritis. I can see why relieving pain is a priority for treatment. I think it is important to remember that pain is a signal that something is wrong and while analgesics provide comfort the cause of pain needs to be addressed also. I wonder if yoga is a good exercise option for people with arthritis since it should be easy on the joints and reduce stress.

    ReplyDelete
  2. Hi Bonnie! I liked how thorough you were in regards to the different types of treatments. But one thing came to mind. It's common knowledge that exercising helps with a lot of different types of diseases and disorders but I was wondering if it works the same with high impact sports and exercises? Like.. would high impact sports (ie, running and jumping rope) be beneficial for arthritis or could it actually be the cause of arthritis and the further exacerbation of this disorder?

    ReplyDelete
  3. Marissa, it actually looks like yoga would be a good options for arthritis patients. Sine it will provide an improvement on their range-of-motion that will help with flexibility and balance!

    Syndey, obviously the severity of the exercises should be determined by each individual and how they are feeling. However, high impact sports should be avoided if they cause pain for the patient. There are alternatives though like cycling or swimming!

    ReplyDelete
  4. Hi Bonnie, great post! You opened my eyes to the many treatments possible for OA. It's definitely reassuring that potential new treatments are always being researched. Hopefully one of these new treatments will replace cortisone shots, as continuous high levels of cortisol in the system might lead to Cushing's-like symptoms. Just a thought, but then again, maybe the frequency and dosage of cortisone shots in the treatment of OA isn't nearly enough manifest as Cushing's.

    ReplyDelete
  5. I love how you mentioned the down side of longer life spans, where there becomes more health concerns, and not just "yay, we live longer." The details of many different treatments were great, it is really eye opening, like John said, that there are so many options. Hopefully new treatments can be successful and more long term relief.

    ReplyDelete
  6. Bonnie, very interesting post. As Marrissa touched on in a previous comment, what I found to be a common thread of these treatments is that they mostly mitigate the downstream effects of OA, in this case the pain. This is similar to something we encountered with inflammatory bowel disease. Many of the medications developed for IBD treated the effects of inflammation rather than preventing what started the inflammation cascade. As you many remember, most of us agreed that it would be more beneficial to stop the inflammation from starting in the first place. I think it would be interesting if we could take that concept and apply it to OA. Specifically I believe it would be more beneficial if we could develop some treatments that work to fix the cause of the pain in the first place, not just cover it up.

    ReplyDelete
  7. Hi Bonnie! This was a great post about all is OA, and your thoroughness definitely answered some questions I had about how OA's pathology. It found the TENS therapy that you mentioned to be very interesting as I had never heard of that type of treatment before, and its cool what they can do by altering pain reception.
    I also enjoyed your discussion of Arthroplasty didn't until your post really put together that most of the patients that I have seen in Physical Therapy must have suffered form OA. It is cool to see that they are making progress in more minimally invasive procedures for these surgeries, because for many older patients the recovery post Arthroplasty can be a very difficult road.

    ReplyDelete
  8. Bonnie discussed above that many of the problems associated with OA come from the loss of cartilage within joints. Theoretically if we could replace that cartilage we could significantly improve the quality of life for patients, and I couldn't help but think of this while reading about the other treatments Bonnie described. I recently read a very interesting article for another class that described many of the difficulties in engineering cartilage for purposes like these. Although cartilage is a rather simple tissue, it does not have a natural healing mechanism because it is largely avascular (lacking blood flow) and acellular (lacking cells). This lack of a natural healing mechanism makes it difficult to integrate a synthetic cartilage so that the joint surface can function as one cohesive whole. There are a number of other challenges in designing a material with properties comparable to human hyaline cartilage and this is an area that bioengineers are continuing to develop. As simple as it sounds, cartilage replacement has been very difficult to achieve. Progress has been made and this may be added to the list of treatments for OA in the future.

    For anyone who is interested, I have cited the article I am referencing below.

    Huey, Daniel J. et al. (2012) “Unlike Bone, Cartilage Regeneration Remains Elusive.” Science 338:917­‐921.

    ReplyDelete
  9. Bonnie, this was a great post! Very comprehensive. I especially liked your comparison of surgical procedures like joint replacement and resurfacing, and how you explained who is eligible for each type of procedure. I am familiar with the recovery of patients who undergo joint replacements, but not so familiar with those who undergo joint resurfacing, so I looked into it a little. It appears that resurfacing is a better option for younger patients who are active, partially because the recovery time is shorter and less stressful on the surrounding tissues. However, resurfacing also appears to be less permanent, and patients likely need repeat surgery or eventual replacement. Interesting to compare the two procedures!
    Thanks for sharing!

    ReplyDelete