Friday, October 4, 2013

Location, Location, Location!

Our environment can have a profound effect upon our systemic health, but our enteric environment, and its flora may have even greater effects. Intestinal microflora is heavily regarded for its impact upon systemic health and contribution to inflammation.  "Resident luminal bacteria seem to be an important factor in the development of IBD [irritable bowel disease] and its chronicity," (1).  In ulcerative colitis, germinated barley foodstuff, or GBF, is found to exhibit a therapeutic-level effect.  GBF is a glutamine-rich protein made from certain fractions of malt, milled and sieved after beer production.  GBF was found in this study to reduce the inflammatory epithelial response on colitis.  Stat-3 expression and NFKB binding activity were found to be inhibited possibly by reducing bile concentrations.  The action of GBF is thought to be its conversion to lactate and acetate by bifidobacterium and lactobacterium which help to preserve the enteric environment.  GBF is considered a "prebiotic."

1. Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment. Osamu Kanauchi, Journal of Gastroenterology
February 2003Volume 38Issue 2pp 134-141

1 comment:

  1. I somewhat agree with the statement that our enteric environment can have more of an effect on our systemic health than other environmental factors we are exposed to. Although, this seems like it could be hard to prove.

    I know that our gut lining is essentially new every three days. This means that we are constantly making new cells and destroying those that are worn out. Something I am curious about is if you can change your gut lining based on your diet. To me, it would make sense that the absence or presence of certain bacteria and cell types would change based on the types of food you consume. In the case that this is true, it would mean that we have an even greater ability to change the state of our systemic health. This could give additional support to the statement that a healthy diet decreases your risk for cardiovascular disease.

    Has anyone seen any research on this?

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