After being assigned this topic, it came to my attention that Inflammatory Bowel Disease, aka IBD, is not the same as Irritable Bowel Syndrome, aka IBS. First and foremost, IBS is not a disease, it is a syndrome, as it's name suggests. The difference between a syndrome and a disease is that a syndrome is a set of symptoms that occur together, and can increase one's chances of developing a disease. A disease on the other hand is a diagnosed impairment of one's health. The commonalities between IBD and IBS are that they both share symptoms of abnormal bowel functions such as pain and/or discomfort in the abdominal area. Irritable Bowel Syndrome does not, however, exhibit any structurally abnormalities that are associated with Inflammatory Bowel Disease such as the existence of Polyps. Also, IBD is associated with inflammation and ulcerations of the mucosa layers of the colon whereas IBS does not exhibit these characteristics. Furthermore, IBD is subdivided into two categories: Ulcerative Colitis and Crohn's Disease.
Another distinguishing factor between IBD and IBS is that IBS is not limited to a homogenous group of individuals, meaning that anybody can develop the clustering symptoms associated with IBs. Whereas IBD is typically seen in individuals of Caucasian and Jewish descent, in women who have a family history of IBD, in higher socioeconomic status, and of individuals in well developed countries.
What intrigues me most is that IBD is common in individuals of higher socioeconomic status. What do you think a reason for this is?
1.) Bradesi, Sylvie, James A. McRoberts,
Peter A. Anton, and Emeran A. Mayer. "Inflammatory Bowel Disease and
Irritable Bowel Syndrome: Separate or Unified?" Medscape Multispeciality (2003): n. pag. Medscape Log In. Web. 13 Oct. 2013. <http://www.medscape.com/viewarticle/457728>.
2.) "Difference Between Syndrome and Disease." Difference Between Similar Terms and Objects.
DifferenceBetween.net, n.d. Web. 13 Oct. 2013.
<http://www.differencebetween.net/science/health/difference-between-syndrome-and-disease/>.
Thank you for the introduction because I didn't know the differences between IBD and IBS! I think the reason may be because since the higher socioeconomic people are able to afford "better" food, there's a certain type of normal flora found in the gut and when "dirty" foods enter the body or other invasive bacteria enter, the higher socioeconomic cannot handle the new microorganisms. When compared to the lower class, they are use to eating these same bacterium and are not bothered. This is my thought at least, but I suppose I'll learn more about it tomorrow I suppose!
ReplyDeleteIBS differs from IBD insofar as IBS is a syndrome consisting of many of the same symptoms as those experienced by people with IBD, without many of the underlying causes. IBS is more easily resolved than IBD, but often IBS is seen to precede the onset of IBD. Mostly trigged by environmental causes rather than involving the genetic immunoinheritance of IBD, IBS can be limited to specific times of stress and lifestyle excesses. This said, however, that IBS can be seen to precede IBD indicates a heavy role for environmental impact upon the progression of the syndrome to disease status. Perhaps one link is the chronic state of IBS without resolution, until IBD becomes a pervasive inflammatory state. IBD is seen mostly associated to specific genetic, ethnic, and environmental associations, along with underlying pathophysiology involving the involvement of non-professional cells behaving as professional cells, TLR and NOD protein involvement, and subsequent NF Kappa B activation.
ReplyDeleteAs to your question about the finding that IBD is found to be prevalent in affluent populations, well, your chart said plenty. Alcoholism rates are highest amongst this group, and can also trigger immune response when the propensity is present and the environmental factors are exacerbated. Affluence often comes with a price, as well, including the psychological stress of keeping up with the Joneses, and in this economy, holding onto what this population already has.
Your title was what caught my attention and to be quite honest, made me a little ashamed to be a Physiology student and not know that there was a difference between the IBD and IBS. Like MEspineira, IBS is easier to resolve in comparison to IBD. IBS does not cause inflammation, ulcers, or other damage to the bowel and I highly doubt that there is as great of a geographical gradient to IBD. One way show the difference between IBD and IBS would be that IBS does not let the bowel do as great of a job as it should while IBD is associate with Crohn's disease and Ulcerative colitis.
ReplyDeleteThank you for this! I found myself getting confused and I noticed other students were too during the discussion when we would say "IBS" and then change it to "IBD". This was a good summary.
ReplyDeleteI think the higher risk for higher socioeconomic people is an interesting subject to discuss. When I first read that they have a higher risk, I thought it ws a mistake. It makes sense to me now that these people have access to cleaner foods and are not exposed to as many pathogens so when they do come in contact with these, they are unable to handle them very well.
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