The purpose of this study was to examine individuals with long standing type II diabetes with kidney failure which is known as diabetic nephropathy. The study compared people with diabetic nephropathy to those with long standing controlled type II diabetes without, nephropathy as well as healthy individuals. The aim of the study was to determine if those with diabetic nephropathy had different levels of circulating inflammatory chemicals, also known as proinflammatory cytokines, compared to those without nephropathy. The study specifically looked at antioxidant levels, BMI, proinflammatory cytokine levels. The study consisted of two hundred people. The subject fasted for eight hours and then had their blood drawn and analyzed.
The study found that those with diabetic nephropathy had higher levels of proinflammatory cytokines and decreased levels of certain antioxidants in their blood. Those with diabetic nephropathy also had lower BMI and hemoglobin when compared to the other groups. They concluded that persistently high blood sugar levels can lead to inflammation which to damage to the kidneys.
Singh, N., Deepak , K., & Nivedita , S. (2012). Type-2 diabetic nephropathy: A proinflammatory cytokine associated disease due to hyperglycemia induced oxidative stress.
Manuscript submitted for publication, Department of Biochemistr y , G.
R. M edical College, Gw alior M.P, , Available from ScopeMed. (JARBS.
2012; 4(2): 137-140)Retrieved from http://www.scopemed.org/?mno=30136
I thought it was really interesting that people with diabetic neuropathy had a lower BMI when compared to individuals with regulated diabetes and control subjects. I wanted to know why this was and the article said it could be due to high protein catabolism and excretion in urine due to renal damage followed by the production of inflammatory markers but they really didn't understand why this was. I would have thought they would have around the same BMI, so I found this interesting to read into.
ReplyDeleteThanks for commenting, yeah I noticed that as well. So I looked around and talked to A few nurses and doctors. From what I gathered, the reason decrease in BMI as the article said is due to increased protein catabolism. In the case of diabetic nephropathy the loss of effective filtration in the kidney leads to a significant increase in protein loss due to poor filtration. To make up for the loss the body spends more energy forming new protein to replace the ones that..well leak out. Think of it like a rowboat, and diabetic nephropathy is a hole in the boat. It takes a lot more energy to row the boat if you have to scoop out water every couple of strokes.
DeleteI'm interested, and also kind of confused, as to why the researchers measured BMI, antioxidant levels, and hemoglobin levels. To me, it seemed that the main focus of the study was to compare the levels of pro-inflammatory cytokines in patients with diabetic nephropathy to those without. Do BMI, antioxidant levels, and hemoglobin play a role in the levels of pro-inflammatory cytokines? If so, how?
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