Since we look at a lot of studies done in mice models, here is one done in humans!
The purpose of this study was to determine if curcumin can delay type II diabetes in adults under the age of 35. 240 test subjects were given a curcumin supplement or a placebo for 9 months. They took 3 curcumin capsules per day, each containing 250mg of Curcumin (in addition to a heather lifestyle). After 9 months, none of the people in the curcumin group were diagnosed with Type II diabetes. (While some in the control group were). The curcumin group also have increase in β-cell function, adiponectin and anti-inflammatory cytokines. They also found no adverse effects from the curcumin supplement amount.
The subjects were given lifestyle modifications for them to have a healthier lifestyle. I thought this helps show, that there is not a "cure all" method. There is still much responsibility of the individual to eliminate as many risk factors as possible if they really want to feel better. This study shows that you don't see overall significant result until after the 6 month period. Those who are looking for the quick fix, will unlikely see beneficial long term results.
In this study you can really see all the variables you have to take into account when doing a study with humans! Such as medications, age, and even the diagnosis method of pre-diabetes or type II diabetes.
I like how in this experiment they really tried to control outside variables like diet and exercise to get a better understanding if curcumin is really the variable that's working. Since it is pretty much impossible to control humans in a manner where all variables (except one) are held constant, I think this experimental design works fairly well to test curcumin's preventive measures.
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